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All animal experiments were performed according to the Guidelines for the Care and Use of Laboratory Animals published by the National Research Council (U.S.) Institute for Laboratory Animal Research and were approved by the Ethics Committee of Zhongshan Hospital, Fudan University, Shanghai, China (approval no

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329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes