First, healthy-user bias is a major concern: individuals prescribed newer, more expensive agents such as semaglutide may systematically differ from comparator groups in terms of health behaviors, dietary patterns, physical activity, adherence to medical care, and access to healthcare resources
The risk of gastroparesis has prompted surgeons to recommend stopping GLP-1 RAs before certain procedures
[13] The combination of NSAID cardiovascular risk with an elevated-cardiovascular-risk patient population on semaglutide represents a clinically significant concern that warrants careful individualized assessment
BMI percent based upon z-score correlated well with baseline fat mass (correlation = 0.475, p = 0.0004)
Diabetes 65 , 24402447 (2016)
Aspen Pharmacare, a South African drugmaker, plans to enter the Canadian market with a generic version of Novo Nordisks blockbuster diabetes and weight-loss drug Ozempic by the third quarter of 2026