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Given the high curing potential, very safe profile (lethal dose not achieved), and with a suitably wide effective range (g-ng regimens) and unlimited methods of application (i.e., intraperitoneal, intragastric, in drinking water or topically, at the site of injury) (for review, see [1,3,4,5,6,8,9,32,33,34])), it may be a real challenge for further therapy

Antidepressants that research has shown to be effective at preventing migraine include nortriptyline, venlafaxine (Effexor), and duloxetine (Cymbalta)

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