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With a sample of 1,014 subjects (789 simvastatin users, 225 atorvastatin users) from the Rotterdam study, they reported that the number of dose reduction or statin switching events significantly ( p = 0.045) increased with the number of A alleles
Efficient GST activity and adequate glutathione are thus important for neutralizing patulin.[ref] Overall, combinations of slower CYP1A2/CYP3A4 alleles with reduced-function GST or UGT variants can leave someone more vulnerable at normal dietary exposure levels, because reactive mycotoxin intermediates may not be cleared efficiently
[DOI] [PMC free article] [PubMed] [Google Scholar] 312
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the Ministry of Science, Innovation and Universities, Spain (Grants RYC-2014-15581, AGL2016-81890-REDT, AGL2017-88329-R and FJCI-2017-31689)
