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Moreover, some recent case-control studies have documented cerebral pantothenic acid deficiency in patients with Alzheimers disease (20) and in those with Huntingtons disease (21)

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Future studies should prioritize (1) isolating and characterizing the active compounds within these botanicals, (2) elucidating their precise molecular targets (e.g., thyroid peroxidase, sodium-iodide symporter, cytokine signaling pathways), and (3) conducting well-designed controlled clinical trials to rigorously evaluate their safety and efficacy in human patients

A pivotal randomized, placebo-controlled trial published in Nutrients administered 200 mg/day of L-theanine to healthy adults for four weeks

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