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This means the problem is not only not enough fuel, but also broken machinery. GSH (Glutathione) depletion links directly to vascular dysfunction, neuropathy, nephropathy, and retinopathy

Two defense-related genes, encoding a GST and a cytochrome P450, were regulated downstream of WRKY45, but were not regulated by NH1, suggesting independence of the WRKY45 and NH1 pathways (Shimono et al., 2007)