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J Clin Oncol 33:19741982 Rudnick SI, Lou J, Shaller CC, Tang Y, Klein-Szanto AJP, Weiner LM, Marks JD, Adams GP (2011) Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors

GSH Nebraska: general info + transporters Comprehensive reviews The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?2017 Tissue distribution and concentration 2-5 mM according to the tissue (5 mM = 1,5366 mg/ml) half-life GSH half life It ranges from 3/5 hours to 30/50 hours If we assume 40kg tissues with an average 2.5 mM GSH (ca 750 mg/l) it means 30 g GSH in the whole body with an half-life of 48hours its life is around 10 days

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The death rate was 11.8% vs 54% in patients who did not take the drug