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healthcare professionals should review concomitant diabetes medicines before and during treatment Delayed gastric emptying as with other GLP-1-based therapies, retatrutide may slow gastric emptying, which could affect the absorption of some oral medicines

Those taking the 4 mg dose of retatrutide, with just a single dose escalation step, lost an average of 47.2 lbs (19.0%)

Finally, the increasing off-label use of GLP-1 RAs for weight loss in non-diabetic individuals may further exacerbate access limitations and drug shortages, potentially disadvantaging patients with T2DM

This suggests the reaction may be more closely associated with the cagrilintide component

Toxicon 62 , 1926 (2013)

Until then, it will be important for clinicians and doctors to screen for these disorders before prescribing these medications