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[13] Meanwhile, in respect to the cardiovascular effects of GLP-1RAs, since several cardiovascular outcome trials (CVOTs) have demonstrated that the cardio-protective effects of GLP-1RAs were independent with glycemic control or weight loss [14-16], GLP-1RAs have been proved with specific cardiovascular benefits

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Indeed, phase 3 clinical trials of retatrutide for type 2 diabetes, non-alcoholic fatty liver disease, and obesity are presently underway (Supplementary Table S2) 10