Indices of glycemic control, such as hemoglobin A1c, glycated albumin, and 1.5-anhydro-d-glucitol were significantly improved after a 3-month treatment with sitagliptin, and serum adiponectin level was significantly increased without changes of body weight [77]
Animal toxicology can identify possible hazards, but species differences prevent it from fully predicting human safety
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Incorrect dosing strength that makes side effects or treatment failure more likely
CONFIRMACIN ESTRUCTURAL E INTEGRIDAD DE LOS ENLACES PEPTDICOS La espectroscopa de RMN o la espectrometra de masas deben confirmar que los enlaces peptdicos estn intactos y que el pptido no est modificado, degradado o sintetizado incorrectamente
reduced active drug delivery obscures true individual responsiveness