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Anal fissures are believed to result from laceration by a hard or large stool or from frequent loose bowel movements Caused by: hard stool passage (constipation), hyperactive sphincter, disease process (e.g., Crohns disease) The fissure may cause internal sphincter spasm, decreasing blood supply and perpetuating the fissure Presents with pain in the anus, painful (can be excruciating) bowel movement , rectal bleeding , blood on toilet tissue after bowel movement, sentinel tag, tear in the anal skin, extremely painful rectal exam, sentinel pile, hypertrophic papilla Diagnosis is made by history and visual inspection +/- anoscopy Alternatively, reproducing the patient's presenting complaints (ie, anal pain) by gentle digital palpation of the posterior (or anterior) midline anal verge is diagnostic A sentinel pile (thickened mucosa) is found below the fissure Unless findings suggest a specific cause or the appearance and/or location is unusual, further studies are not required For patients with a typical anal fissure (ie, a single posterior or anterior fissure with no evidence of Crohn's disease ), treatment consists of a combination of supportive measures (fiber, sitz bath, topical analgesic) and one of the topical vasodilators (nifedipine or nitroglycerin) for one month
(1994): In vivo serotonin release and learned helplessness
With GLP-1 receptor agonists in the mix, glucagon secretion takes a back seat, leading to a decrease in glucose production in the liver
The impact of taurine supplementation on human exercise performance is less clear
