Other Candidate Mechanisms for Balancing Plasticity at Excitatory Inputs to Inhibitory Neurons Although the problem of balancing changes at excitatory synapses in interneurons during ongoing associative learning has received little attention so far, a large body of research into the same problem in excitatory neurons has suggested a number of solutions that could be applicable for inhibitory neurons too
Alternatively, the glutathione pool could increase until a threshold has been reached, which elicits a competitive feedback inhibition, in which glutathione competes with glutamate for glutamate cysteine ligase, limiting the rate of the primary synthesis reaction (Reference Richman and Meister53)
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Importantly, experts caution that GLP-1 drugs are not yet approved for neurodegenerative diseases, and further large-scale trials are needed to confirm efficacy
Peptides (1995) 16:6415
Like most wellness practices, the benefits of B12 and lipotropic injections are cumulative