Stress can exacerbate existing psoriasis or even trigger its onset ( Obesity: Adipose tissue in obese individuals can promote the production of pro-inflammatory cytokines, potentially contributing to the chronic inflammation characteristic of psoriasis ( Infections: Some researchers suggest a possible role for infections, particularly those involving streptococcal bacteria, in triggering guttate psoriasis ( Other environmental factors: While the evidence is less conclusive, alcohol consumption and certain medications have also been implicated in psoriasis pathogenesis ( 3.2 Current psoriasis treatment landscape: progress and challenges Psoriasis treatment strategies are tailored to disease severity, patient characteristics, and treatment efficacy and safety profiles ( 3.2.1 Conventional systemic treatments Psoriasis is traditionally treated with methotrexate, a systemic medicine known for its cytotoxic, anti-inflammatory, and immune-modulatory effects, making it therapeutically valuable
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