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The new methods have to be not only effective in removal of pharmaceuticals (and their metabolites) but also apply relatively low toxic chemicals and, what is not less important, they should be acceptable from the economic point of view

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10.1016/S2213-8587(19)30194-9 Lancet Diabetes Endocrinol

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Given that a variety of cells in the lymph nodes possess the ability to express PD-L1, including LECs (94, 95, 98), FRCs (215), dendritic cells (203), macrophages, B cells, T cells, and NK cells (204, 208, 209), understanding the impact of PD-1/PD-L1 immune checkpoint blockade on these cells and their interactions with T cells in the TDLNs might provide novel solutions to further enhance the efficacy of immunotherapy