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Neurology 1991;41:1726-32

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

8,9 The treatment of hemolytic anemia due to oxidative stress in patients with G6PD deficiency consists of supportive care such as stopping the offending stressor, treating the underlying cause, such as in cases of diabetic ketoacidosis, in addition to supplemental oxygen and blood transfusions

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Their system protected siRNA from degradation under normal conditions but enabled rapid release in GSH-rich cancer environments, achieving widespread brain distribution within 2 h and persistence up to 24 h