Attaching of N -Boc-norleucine, removal of Boc, acetylation of norleucine amino group with acetic anhydride, HF mediated cleavage of the resulting peptide from the polymer support, and finally purification using RP-HPLC afforded the target compound 2 in 5560% overall yield [18,24]
however, the patient still had short stature and a height SDS of 3.3
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