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A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo

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GLP-1 agonists are not approved for cosmetic weight loss in individuals at a healthy weight

One in vitro study reported that exendin-4 increases the number of neurites, promotes neuronal outgrowth, and considerably increases neurite length (Luciani et al., 2010)

Walker's explanation helps justify caffeine consumption -- the bitter detection system is giving a false alarm, but the compound is actually beneficial