Functional experiments confirmed that, compared with exosomes from healthy pregnant women, exosomes from GDM patients increased the expression of genes related to glycolysis and gluconeogenesis in placental cells, suggesting that adipose tissue-derived exosomes contribute to GDM pathology by regulating placental metabolism
10.1038/s41586-021-03539-7 Nature
4 Adverse effects: Tirzepatide vs GLP-1 RAs In clinical trials, the main cause of discontinuation of tirzepatide was adverse events that seem to be qualitatively and quantitatively comparable to those reported in patients treated with GLP-1 Ras, and they are more common at the higher dose of tirzepatide, supporting a dose-dependent safety profile (47, 48)
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Wegovy significantly reduced the risk of major adverse cardiovascular events (cardiovascular death, heart attack and stroke), which occurred in 6.5% of participants who received Wegovy compared to 8% of participants who received placebo
