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According to Durkin, several committee members appeared to view FDAs assessment as applying an overly restrictive standard for evaluating compounded peptides, while FDA scientists emphasized the limited clinical evidence supporting many of the substances

But later studies have not confirmed this

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After 28 weeks, the results showed people in each of the treatment groups lost on average: 20 pounds (lb) with a combination treatment of 15 milligrams (mg) phentermine with 92 mg topiramate 13.6 lb with 15 mg phentermine only 14.7 lb for 92 mg topiramate only This suggests that taking the drugs together rather than separately may result in greater weight loss