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Johnson W BW, Belsito DV

10.1172/JCI200215715 J

Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, those with severe hypersensitivity to tirzepatide, and should be used cautiously in patients with history of pancreatitis or severe gastrointestinal disease

However, these beneficial effects are antagonized by pro-inflammatory adipokines such as tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6), which inhibit adiponectins activity

These cells were further characterized as containing large (canine) to medium (human) solid round granules by electron microscopy and termed L-cells (11)