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For the underlying pharmacology and trial efficacy that justifies any spend on these drugs, see (Jastreboff et al., 2022) for tirzepatide SURMOUNT-1 and (Wilding et al., 2021) for semaglutide STEP-1

One study from February 2025, for instance, suggests that people who take glucagon-like peptide-1 receptor agonist medication like Ozempic to treat diabetes have a lower depression risk than peers taking other types of drugs for this metabolic condition

However, the NDC number will differ from the commercial product NDC because the compounding pharmacy assigns its own NDC to compounded preparations

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Zepbound (tirzepatide): about $299 per month for the starting dose, rising to roughly $449 and higher for higher maintenance doses