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Below are symptoms that occur with those diagnoses: Major Depressive Disorder Feeling sad, empty or hopeless Not feeling interested in or enjoying things that you used to like Difficulty concentrating on everyday tasks Low self-esteem or excessive guilt about things Pessimism about the future Thoughts about death Insomnia or oversleeping Overeating or undereating, which can lead to weight changes A constant feeling of fatigue Generalized Anxiety Disorder Unexplained fear or excessive worry Agitation or restlessness Irritability or becoming easily annoyed Issues falling or staying asleep Brain fog or difficulty thinking clearly Lexapro can also be used off-label (not approved by the FDA) for other mental health diagnoses including obsessive-compulsive disorder, post traumatic stress disorder, panic disorder, social anxiety disorder and some eating disorders