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Diabetes-induced glucose metabolism disorders have a profound impact on spermatogenesis through multiple mechanisms, including lipid metabolism abnormalities, changes in epigenetic modifications, mitochondrial dysfunction, and glycolysis abnormalities [67, 160, 216]

Type of GLP-1 RA used (liraglutide, semaglutide, dulaglutide)

Ovothiol (105) induces apoptosis and autophagy in GGT-overexpressing cells

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Additionally, PAI-1 not only acts as a key mediator of TGF--induced senescence but also forms a cascade amplification effect through the activation of the p53-p21-retinoblastoma (Rb) protein signaling axis, ultimately leading to AT2 cell senescence [72, 73]

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