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Rac, a small protein that belongs to the Rho family of GTPases, acts as an activator of NADPH oxidase that generates ROS for various purposes [177]

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When GIP receptor activation combines with GLP-1 stimulation, as it does with tirzepatide dosing protocols , the result is enhanced insulin sensitivity, improved lipid metabolism, and a reduction in pathological fat deposition

In this context, carriers of apolipoprotein 4 (APOE4) allele, a major risk factor for AD, present with pericyte degeneration and associated BBB breakdown [42], which has been recently associated with cognitive decline, independent of AD pathology [43]

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