Therefore, taken together, these limitations reflect the need for developing a more accessible and simpler assay that can measure the rate of NADPH consumption by a specific pathway, such as the one mediated by glutathione-disulfide reductase (GSR)
Any pathological process that can disrupt these interconnected metabolic hubs, such as mitochondrial dysfunction in PD or oxidative stress in AD, may inadvertently lower the cellular threshold for resistance to ferroptosis
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A breakthrough discovery changed all that