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Studies showed that CCR3 activation promotes human choroidal endothelial cell migration, proliferation and angiogenesis in the choroidal neovascularization, each of which (eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26) exerts the same effect through CCR3 [48]

3 The gastrointestinal side-effect profile seen across its trials is the clinical fingerprint of that mechanism

Maintenance (Step 4+, ~week 13 onward): hold at the tolerated target (e.g

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Neither has completed comprehensive Phase 3 safety trials for tissue healing, so long-term human safety data remains limited for both