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For women, the risk was 26%

Noskipping or halving doses disrupts your medication's steady-state levels and may reduce weight-loss effectiveness

This slower movement can increase water absorption in some people while causing looser stools in others, depending on individual gut sensitivity and baseline microbiota composition

Tong et al., 2015

GLP-2 affects gut motility and is an intestinal trophic factor, with therapeutic potential for the treatment of intestinal disorders such as short bowel syndrome [9]

And TRANSCEND-T2D-1, part of a separate three-trial diabetes-specific program, confirmed -2.0% HbA1c reduction and 16.8% weight loss in 537 type 2 diabetes patients (topline March 2026, published in The Lancet, June 2026)