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When a muscle is stimulated by a nerve impulse, Ca2+ is released from the sarcoplasmic reticulum into the cytoplasm of the muscle fiber

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Chronic hyperuricemia always accompanied with multiple complications such as kidney injury, non-alcoholic fatty liver and metabolic syndrome

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Previous studies documented the protective effects of Hsp70 for maintaining lysosomal integrity, showing that it can stabilize lysosomal membrane by binding to lipid bisphosphonates and enhancing the activity of acidic sphingolipase 78,79

Hatzichristou DG