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These effects explain most early weight loss on therapy

The cardiovascular protection data comes primarily from studies lasting 1-4 years, suggesting this is a long-term strategy rather than a short-term intervention

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Probabilistic sensitivity analysis showed semaglutide dominated liraglutide in 80.8% of simulations (greater QALYs and lower costs) and reached 100% probability of cost-effectiveness at a willingness-to-pay threshold of 9,000 per QALY

In an early phase 1 study of healthy obese participants, setmelanotide demonstrated significant weight loss compared to baseline for all treatment groups receiving 0.01 mg/kg/24 h via SC infusion (NCT02431442) (85, 86)

Type 2 diabetes requires ongoing medical oversight unfit for exclusive telehealth care, whereas weight loss management is well-suited for telehealth consultations at Klinic