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High doses of ursodeoxycholic acid up-regulate the expression of placental breast cancer resistance protein in patients affected by intrahepatic cholestasis of pregnancy

A 4mg dose = 0.4mL = 40 units

Naturally occurring in the liver, it is the bodys natural detoxifier which works to clear toxins from the body

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RCM of two R -configurated amino acids forming an R ( i , i + 4) R (8) staple also proceeds efficiently, but this particular staple neither stabilizes helices well nor provides peptides with high cell-penetrating ability, and RCM reactions using one R - and one S -configurated amino acid are found to be very inefficient [83]

After thiamine is released into the cell, the ancillary mercaptan group must also be processed and/or detoxified through alternative pathways