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Positive modulations of gut microbiota by prebiotics also help to maintain the integrity of the gut barrier and promote the production of beneficial metabolites such as short-chain fatty acids, which have anti-inflammatory and protective effects on the gut lining and reduce gut-related disorders in the fish

Ultimately, this cycle drives immunosuppressive cold tumors toward a self-sustaining hot state, tipping them into a trajectory of immune-mediated self-destruction

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A favorable milieu for uric acid kidney stone formation may be created by a lower urine pH resulting from defective ammonium production associated with insulin resistance, common in MASLD