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By analyzing proliferation markers typical of young neurons, some studies have ascertained that the degree of postnatal neurogenesis in the dentate gyrus drops sharply in childhood to become absent in adults ([22, 42] but see also [43])

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The higher Rg values of the mGLP1-DARPin-1 and mGLP1-DARPin-2 fusion proteins than the nGLP1-DARPin indicate loose packing of the protein structure in the mutant systems, which means more flexible conformation