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Disclaimer: This spotlight is provided for educational purposes to acknowledge scientific contributions to GLP3 research and development

doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date

GLP-1 increases insulin release, decreases glucagon, slows stomach emptying, and enhances satiety to control blood sugar

Yes, orforglipron (Foundayo) is effective for weight loss in non-diabetics

It works by targeting three pathways as opposed to one for semaglutide and two for tirzepatide, creating a powerful effect on appetite and blood sugar regulation