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Preliminary multimodal trials and mechanistic studies, such as the SYNERGIC and PONDER frameworks and the combined exercise plus vitamin D work by Hoseini and colleagues, suggest that integrating these interventions may produce additive or synergistic neuroprotective effects, but a consolidated, aging-centered synthesis is lacking (1315)

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It should be interpreted with your provider as one context-setting tool alongside your TRT status and overall health profile

Although semaglutide causes the stomach to empty more slowly, leading to gastrointestinal symptoms like bloating, no significant evidence shows that it increases the risk of colon perforation

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