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Sirtuins have seven isoforms in humans, Sirt17, whose deacetylase activity and cellular localization differ widely from each other, although their family of proteins share a catalytic domain that is conserved among all sirtuins

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In a lung ischemiareperfusion model, nitrite attenuated mitochondrial impairment and vascular permeability, supporting the concept that NO-dependent mitochondrial modulation can mitigate reperfusion-associated injury (124)