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Furthermore, pathogenic variants in LONP1 are a primary cause of large antral follicle deficiency, infertility, and premature ovarian failure in females

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(ii) SG/mKate2 double-positive cells were considered to be in the process of death, and thus counts of double positive cells were subtracted from the counts of live cells

Moreover, fibrotic vascular remodeling induces tissue hypoxia, stabilizing HIF-1, which drives vascular endothelial growth factor (VEGF)-dependent angiogenesis and metabolic reprogramming toward aerobic glycolysishallmarks of tumor progression