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It can be triggered by allergies, irritants, hormonal changes, or underlying skin conditions like atopic dermatitis

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These agents require careful dose titrations due to their adverse drug event (ADE) profile, which commonly includes nausea and vomiting

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The mechanisms by which methimazole and/or PTU cause hepatotoxicity are not clarified completely yet, but it seems that these mechanisms might be different between currently available antithyroid drugs.29 Furthermore, the risk factors that render patients more susceptible to antithyroid drugs-induced hepatic injury are not fully recognized