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Grillo A, Salvi L, Coruzzi P, Salvi P, Parati G

38 This pain commonly presents as spontaneous burning sensations in the feet, and patients may also report positive sensory symptoms such as brush-evoked allodynia (pain from normally non-painful stimuli) and paresthesias, which are often accompanied by sensory loss, leading patients to describe the paradox of their feet being continuously painful yet insensate to touch

For secondary LONP1-related diseases, therapeutic targets can extend beyond LONP1 itself to upstream and downstream pathways, including MPC1 agonists for metabolic reprogramming, CYP11A1 inhibitors for hormone synthesis regulation, or TGF- inhibitors for fibrosis modulation

doi: 10.14814/phy2.13994 40 MannJ

Because NAD+ is a form of vitamin B3-related compound, true allergic reactions are uncommon