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After excluding case reports and letters, and subsequent review of abstracts and full - texts, a total of 219 articles were included for evaluation in this manuscript

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The pathophysiology involves complex interactions of endocrine, immunologic, and inflammatory processes, with retrograde menstruation as the most accepted theory for ectopic tissue implantation (6).Estrogen metabolism and chronic inflammation are key pathophysiological mechanisms, with emerging evidence highlighting the microbiomeparticularly the gut and genital tract microbiotain modulating estrogen metabolism and inflammation, potentially influencing disease etiology and symptomatology (7)

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Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice