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Effects of Kynurenine pathway inhibition on NAD+ metabolism and cell viability in human primary astrocytes and neurons

In part, this reflects excitation/inhibition balance and classical aminergic neuromodulatory tone in the brain, both of which are deranged by excess nitrogen and can ultimately cause excitotoxicity if nitrogen imbalances are not promptly addressed (Rangroo Thrane et al., 2013)

Tendon thickness and echotexture on ultrasound

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