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The provider adjusts dosing over time based on the patient's tolerance, side effects, and weight loss progress

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Utilization of PBPK Modeling Approaches to Assess DDIs Caused by Mechanisms of Actions Evaluating the mechanism of action (eg, delayed gastric emptying, reduced fat mass and inflammation, and changes in GFR)-mediated DDIs of GLP-1 RAs and a dual GLP-1/GIP RA is often challenging to control for and clinical studies are costly

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Conversely, ferroptosis inhibitors, such as iron chelators, including deferoxamine (DFO), or GPX4 activators, have been shown to mitigate IDD progression, suggesting a potential therapeutic approach (4,46)

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