Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g., carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, hepatic impairment, and mitochondrial diseases [see Warnings and Precautions (5.1)]
Stay hydrated throughout the day, as dehydration worsens both nausea and the medication's side effects
However, this also depends on the type of plan and the medical history of the patient in question. In addition to weight management, Wegovy is also FDA approved to reduce the risk of major adverse cardiovascular events in adults with cardiovascular disease and either obesity or overweight
Salmon WD
Clinical trials indicate that participants lost an average of 20.9% of their body weight
Increased Risk of Pancreatitis Both medications carry a known, though rare, risk of inflammation of the pancreas (pancreatitis)
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