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However, other PDZ-binding proteins are known to also regulate CFTR localization and function, including NHERF2 55,84 , CAL (CFTR-associated ligand) 85 , and CAP70 (CFTR associated protein) 86 Furthermore, other non-PDZ-dependent mechanisms may contribute, since the physiologic dimers of CFTR are assembled independently of either NHERF1 or NHERF2, thus leaving PDZ-domains available for other interactions 55

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For widespread skin conditions (psoriasis, systemic dermatitis), subcutaneous injection at 200 to 500 mcg/day may be more effective than topical alone

Table 9.231 International serum gamma-tocopherol and alpha-tocopherol concentrations (uM/L)1 There are 3 different studies that have reported serum levels in the United States

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Injectable GHK-Cu after reconstitution must be refrigerated - no exceptions