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This ensures the best treatment outcome

The therapeutic window is wide, but dosing below 5 mcg/kg risks falling below the efficacy threshold observed in gastric ulcer models

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5 m-thick sections were stained with hematoxylin and eosin (H&E) or picrosirius red solution (Abcam #ab150681) following manufacturers protocol as previously described ( 2.8 Statistical analyses All the data are presented as mean SEM and analysed by unpaired two-tailed Students t-test or two-way ANOVA with Bonferroni or Tukeys post-hoc test as appropriate using GraphPad Prism