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2011;6:e21398

In Chronic Obstructive Pulmonary Disease (COPD), hypermethylation of the NRF2 promoter leads to decreased NRF2 expression in the lungs of patients, resulting in the inhibition of the NRF2-GPX4 axis and subsequent induction of ferroptosis

The term originates in the pharmacology community, defined as the rate at which a drug can reach the targeted action site

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Mucosal damage, such as in ulcers of patients with inflammatory bowel disease (IBD), disrupts this complex regulatory structure and causes an uncontrolled leakage through the barrier (2628) (Figure 1)