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J Clin Endocrinol Metab (2021) 106(3):91221

To this end, a hyperglycemic clamp in DIO mice treated with vehicle, cotadutide, liraglutide, or g1437 for 7 days was conducted in the absence of exogenously administered insulin, prior to potential BW loss adaption

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observed nearly similar results of our ultrastructural observations in MTX-treated rats and reported that rats administered a low dose of MTX (1 mg/kg once weekly) had severe renal tissue damage and disturbance in renal functions, which was linked to elevated oxidative stress as well as MTXs pro-inflammatory and pro-apoptotic effects