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Contact your GP or prescribing clinician promptly if you experience any of the following whilst taking ondansetron and Wegovy together: Severe or persistent gastrointestinal symptoms : Nausea or vomiting that prevents you from keeping down fluids or medications for more than 24 hours Severe abdominal pain, particularly if constant, severe, or radiating to your back (potential sign of pancreatitis) Signs of dehydration: dark urine, dizziness, reduced urination, extreme thirst, or confusion Persistent diarrhoea or constipation lasting more than a few days If you experience severe abdominal pain that may indicate pancreatitis, stop taking semaglutide immediately and seek urgent medical assessment