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Antioxidant Deficiencies in Hospitalized Dogs and Cats [State of the Art Lecture] Reactive oxygen species (ROS) are molecular oxygen metabolites that are highly reactive with lipids, proteins, and DNA, causing oxidative damage to these cellular macromolecules

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Both amide bond-forming enzymes display notable biocatalytic potential, including scalability, stereoselectivity toward the warhead and broader substrate scopes in forming the amide bonds

We do not know the optimal human dosing, long-term safety profile in humans, or whether animal results translate directly to human outcomes

The impact of GEP12 on food intake relative to baseline was notably less than that observed in response to GEP44 (at 5 nmol/kg/day: mean difference 36.5%, 95% CI 14.9% to 58.0%, p = 0.0009