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The GPX4 isoforms mGPX4 and nGPX4 have been implicated in spermatogenesis and male fertility

Yeah, absolutely

This results in progressive telomere shortening over time, acting as a biological clock that caps the number of possible cell divisions (Harley et al., 1990)

Furthermore, several metabolites, such as bilirubin and melatonin, have antioxidant effects [60, 61]

The oocytes were subsequently incubated in a permeabilizing solution (0.5% Triton-X-100 in PBS-PVA) for 30 min at room temperature, washed twice in PBS-PVA, and then blocked with 2% FCS in PBS for 45 min

Sarcosine is uniquely modulated by aging and dietary restriction in rodents and humans