Originally developed as a potential treatment for skin conditions like erythropoietic protoporphyria, it has gained popularity for its ability to enhance skin pigmentation, leading to an increased interest among individuals seeking tanning solutions
Injectable Semaglutide Injectable versions are administered subcutaneously (under the skin) once a week
The therapeutic effect of compounded semaglutide or tirzepatide comes from the active ingredient and the dose, not the delivery device
We began with the most challenging endpoint possible (extension of median and maximal lifespan) in a very rigorous, well-controlled study (the NIA ITP), checked that rapamycin performed well in that setting, then only afterward began considering individual, smaller, less well-controlled studies of alternate endpoints like muscle mass and hearing loss
I also measure the signaling hormones TSH, LH & FSH, as well as things that can inhibit normal signaling, like estradiol, prolactin, inflammation, blood sugar, growth hormone, and micronutrient deficiencies
The consequence of this interaction is the breakdown of immune tolerance, manifested by the proliferation of follicular helper T (Tfh) and Th17 cells, impaired function of Tregs, aberrant B-cell activation leading to excessive autoantibody production, elevated levels of inflammatory mediators, multiorgan inflammation, and tissue damage, ultimately culminating in the development of autoimmune disorders
